TABLE 1.

Deletion or insertion of Brucella genes resulting in attenuated bacteria

Gene	Function	Species	Virulence		References
			In vitro	In vivo
pgm	Phosphoglucomutase (LPS synthesis)	B. abortus	Virulent	Attenuated	156
rfbE	Perosamine synthetase (LPS synthesis)	B. melitensis	Virulent	Attenuated	65
pmm	Phosphomannomutase (LPS synthesis)	B. abortus	Attenuated	Attenuated	2
wboA	Glycosyltransferase (LPS synthesis)	B. abortus	NDa	Attenuated	104
cydB	Cytochrome bd oxidase (respiratory system)	B. abortus	Attenuated	Attenuated	54
cgs	Cyclic β-1,2 glucan synthetase	B. abortus	Attenuated (only S19)	Attenuated (only S19)	23, 77
sod	Cu-Zn SOD	B. abortus	Virulent	Attenuated (only S2308)	154
dnaK	Heat shock protein	B. suis	Attenuated	NDa	93
lon	Protease	B. abortus	Attenuated	Virulent	135
bacA	Cytoplasmic membrane transport protein	B. abortus	Attenuated	Attenuated	98
hfq	Host factor-1, RNA-binding protein regulating stationary-phase stress resistance	B. abortus	Attenuated	Attenuated	136
virB	Type IV secretion system	B. suis, B. abortus	Attenuated	Attenuated	59, 75, 116, 146
bvrRS	Two-component regulatory protein	B. abortus	Attenuated	Attenuated	147
aroC	Chorismate synthase (aromatic compound synthesis)	B. suis, B. abortus	Attenuated	Attenuated	59, 60, 75
purE	De novo purine synthesis pathway	B. melitensis	Attenuated	Attenuated	41, 49, 76

^aND, not determined.