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. 2003 Jan;16(1):65–78. doi: 10.1128/CMR.16.1.65-78.2003

TABLE 2.

Brucella infection in gene KO or immunocompromised mice

Mouse strain Function Deficient phenotypes Species Result of infection Reference(s)
IRF-1−/− IRF-1 IL-12, IL-15, IL-18, iNOS, CD8+ T cells, NK cells B. abortus Acute death 89
IRF-2−/− IRF-2 IL-12, NK cells B. abortus Resistant 89
ICSBP−/− ICSBP IL-12, ROIs B. abortus Susceptible 89
NOS2−/− iNOS Nitric oxide in macrophages B. abortus Delayed control 89
gp91phox−/− NADPH oxidase component NADPH oxidase-dependent ROIs B. abortus Delayed control 89
IL-12p40−/− IL-12 component IL-12 B. abortus Susceptible 89
IFN-γ−/− IFN-γ IFN-γ B. abortus Death (C57BL/6 and BALB/c) 113
TNFR−/− TNF receptors 1 (p55) and 2 (p75) TNF-α signaling B. abortus Susceptible 168
NF-IL-6−/− Nuclear factor IL-6 G-CSF B. abortus Susceptible in vitro 127
β2-m−/− MHC class I β2-microglobulin CD8+ T cells B. abortus Susceptible to S19, resistant to S2308 113, 119
−/− MHC class II Aβ chain CD4+ T cells B. abortus Resistant 119
Rag-1−/− Recombination activation gene 1 Matured B and T cells B. melitensis Susceptible 79
SCID Lacks mature B and T cells Matured B and T cells B. abortus Resistant Morfitt et al.a
Nude Thymic stroma, matured T cells Lacks matured T cells B. abortus Susceptible (persistence) 32
Perforin−/− CTL killing Absence of perforin-mediated killing B. abortus Resistant 113
a

D. C. Morfitt, N. F. Cheville, and A. E. Jensen, Proc. Conf. Res. Workers Anim. Dis. 72:2, 1991.