TABLE 2.
Mouse strain | Function | Deficient phenotypes | Species | Result of infection | Reference(s) |
---|---|---|---|---|---|
IRF-1−/− | IRF-1 | IL-12, IL-15, IL-18, iNOS, CD8+ T cells, NK cells | B. abortus | Acute death | 89 |
IRF-2−/− | IRF-2 | IL-12, NK cells | B. abortus | Resistant | 89 |
ICSBP−/− | ICSBP | IL-12, ROIs | B. abortus | Susceptible | 89 |
NOS2−/− | iNOS | Nitric oxide in macrophages | B. abortus | Delayed control | 89 |
gp91phox−/− | NADPH oxidase component | NADPH oxidase-dependent ROIs | B. abortus | Delayed control | 89 |
IL-12p40−/− | IL-12 component | IL-12 | B. abortus | Susceptible | 89 |
IFN-γ−/− | IFN-γ | IFN-γ | B. abortus | Death (C57BL/6 and BALB/c) | 113 |
TNFR−/− | TNF receptors 1 (p55) and 2 (p75) | TNF-α signaling | B. abortus | Susceptible | 168 |
NF-IL-6−/− | Nuclear factor IL-6 | G-CSF | B. abortus | Susceptible in vitro | 127 |
β2-m−/− | MHC class I β2-microglobulin | CD8+ T cells | B. abortus | Susceptible to S19, resistant to S2308 | 113, 119 |
Aβ−/− | MHC class II Aβ chain | CD4+ T cells | B. abortus | Resistant | 119 |
Rag-1−/− | Recombination activation gene 1 | Matured B and T cells | B. melitensis | Susceptible | 79 |
SCID | Lacks mature B and T cells | Matured B and T cells | B. abortus | Resistant | Morfitt et al.a |
Nude | Thymic stroma, matured T cells | Lacks matured T cells | B. abortus | Susceptible (persistence) | 32 |
Perforin−/− | CTL killing | Absence of perforin-mediated killing | B. abortus | Resistant | 113 |
D. C. Morfitt, N. F. Cheville, and A. E. Jensen, Proc. Conf. Res. Workers Anim. Dis. 72:2, 1991.