TABLE 3.

Brucella antigens that induce a B-cell response

Antigen	Function	Species	Serum host	Protection	Reference(s)
Omp19	Outer membrane protein	B. abortus	Mouse, goat, dog, human	NDa	94
Omp25	Outer membrane protein	B. ovis	Mouse	Yes	18
Omp28	Outer membrane protein	B. melitensis	Human	ND	102
Omp31	Outer membrane protein	B. ovis	Ram	Yes	88
Omp89	Outer membrane protein	B. abortus	Cattle	ND	100
CP24	Ribosome-releasing factor	B. melitensis	Sheep	ND	159
HtrA	Heat shock protein	B. abortus, B. melitensis, B. canis	Mouse, cattle, goat, dog	ND	138
18-kDa protein	Lumazine synthase	B. ovis, B. canis	Human, cattle	ND	8, 66, 67
BCSP31	Unknown	Brucella spp. except B. ovis	Rabbit	ND	20
DnaK	Heat shock protein	B. melitensis, B. ovis	Mouse, sheep	ND	155, 160
BP26 (CP28)	Periplasmic or cytoplasmic protein	B. abortus, B. melitensis	Cattle, human, ram	ND	42, 140
17-kDa protein	Unknown	B. abortus, B. melitensis	Sheep, cattle	ND	70
22.9-kDa protein	Unknown	B. abortus	Unknown	Yesb	30
32.2-kDa protein	Unknown	B. abortus	Unknown	No	30
20-kDa protein (antigen A-2)	Unknown	B. melitensis	Unknown	ND	148, 173
Dihydrolipoamide succinyltransferase	Dihydrolipoamide succinyltransferase	B. ovis	Mouse	ND	155
31-kDa protein	Unknown	B. ovis	Unknown	ND	155
Malate dehydrogenase	Malate dehydrogenase	B. ovis	Unknown	ND	155
Succinyl coenzyme A synthetase alpha subunit	Succinyl coenzyme A synthetase alpha subunit	B. ovis	Unknown	ND	155
ABCa-type transporter	ABC-type transporter	B. ovis	Unknown	ND	155
Leu/Ile/Val-binding-protein precursor	Leu/Ile/Val-binding-protein precursor	B. ovis	Unknown	ND	155
ClpP	Stress protein	B. ovis	Unknown	ND	155
NikA	Nickel transport	B. ovis	Unknown	ND	155

^aND, not determined; ABC, ATP-binding cassette.

^bWith Freund’s adjuvant.