TABLE 4.

Brucella antigens that induce a T-cell response

Antigen	Function	Species	Host	Protection	Reference(s)
P39	Periplasmic binding protein	B. melitensis	Guinea pig, cattle, mouse	Yes, with CpG	3, 45, 46
Bacterioferritin	Iron-binding protein	B. melitensis	Guinea pig, cattle, mouse	Yes, with CpG	3, 46
GroEL	Heat shock protein	B. abortus	Mouse, guinea pig	NDa	117, 118, 120, 150
GroES	Heat shock protein	B. abortus	Mouse, guinea pig	ND	117, 120
YajC	Transmembrane protein	B. abortus	Mouse	ND	158
UvrA	DNA repair enzyme	B. abortus	Cattle, mouse, guinea pig	ND	117, 120, 172
L7/L12	Ribosomal proteins	B. abortus	Mouse	Yes, with Freund's adjuvant	117, 120
BA14K	Unknown	B. abortus	Mouse	ND	34
SOD (BCSP20)	Cu-Zn SOD	B. abortus	Cattle, mouse	Yes, but synthetic peptide	21, 152, 153
31 kDa	Unknown	B. abortus	Cattle	ND	25

^aND, not determined; CpG, unmethylated synthetic CpG oligonucleotides.