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. 2003 Feb;71(2):857–863. doi: 10.1128/IAI.71.2.857-863.2003

FIG. 4.

FIG. 4.

Duration of protection induced by CpG-ODN. Chickens were treated with 10 μg of CpG-ODN(2007) by the subcutaneous route on day 10 (□), 13 (*), 16 (⧫), 19 (▾), or 22 (▴) and challenged with E. coli on day 25 (n = 24). Birds were significantly protected (P < 0.01) by administration of CpG-ODN(2007) 3 days prior to challenge with E. coli, and the protection decreased with increasing interval between treatment and challenge. ▪, control.