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Effects of nafuredin on electron transport enzymes
| IC50 (nM)
|
|||||
|---|---|---|---|---|---|
| Complex | Ascaris suum (adult) | Ascaris suum (L2) | Haemonchus contortus (adult) | Rat liver | |
| NADH-fumarate reductase | I + II | 12 | — | — | 1,000 |
| NADH-ubiquinone reductase | I | 8 | 8.9 | 86 | 10,000 |
| NADH-rhodoquinone reductase | I | 24 | 9.0 | 195 | >100,000 |
| Rhodoquinol-fumarate reductase | II | 80,000 | — | — | — |
| Succinate-ubiquinone reductase | II | >100,000 | — | — | >100,000 |
—: Not tested.
