Abstract
The aim of this study was to assess the incidence of monoclonal proteins, during a 7-year period, in the population served by a typical District General Hospital. 183,300 sera were electrophoresed and 804 monoclonal proteins were detected. Various biochemical prognostic criteria, such as the concentration of monoclonal protein, incidence of Bence-Jones protein and the presence of reduced polyclonal immunoglobulins, were studied in an attempt to assess the benign or malignant nature of the monoclonal protein. In this study, 75% of the patients with monoclonal proteins fulfilled at least one of these criteria, demonstrating the importance of long-term monitoring.
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Selected References
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- Axelsson U., Bachmann R., Hällén J. Frequency of pathological proteins (M-components) om 6,995 sera from an adult population. Acta Med Scand. 1966 Feb;179(2):235–247. doi: 10.1111/j.0954-6820.1966.tb05453.x. [DOI] [PubMed] [Google Scholar]
- Carter A., Tatarsky I. The physiopathological significance of benign monoclonal gammopathy: a study of 64 cases. Br J Haematol. 1980 Dec;46(4):565–574. doi: 10.1111/j.1365-2141.1980.tb06013.x. [DOI] [PubMed] [Google Scholar]
- Hobbs J. R. Immunoglobulins in clinical chemistry. Adv Clin Chem. 1971;14:219–317. doi: 10.1016/s0065-2423(08)60147-x. [DOI] [PubMed] [Google Scholar]
- Hobbs J. R. Paraproteins, benign or malignant? Br Med J. 1967 Sep 16;3(5567):699–704. doi: 10.1136/bmj.3.5567.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kitamura M., Yamaguchi H., Murakawa K., Murao T., Iizuka Y. Screening for multiple myeloma using routine laboratory test results. Clin Biochem. 1982 Feb;15(1):17–21. doi: 10.1016/s0009-9120(82)90331-9. [DOI] [PubMed] [Google Scholar]
- Kyle R. A., Finkelstein S., Elveback L. R., Kurland L. T. Incidence of monoclonal proteins in a Minnesota community with a cluster of multiple myeloma. Blood. 1972 Nov;40(5):719–724. [PubMed] [Google Scholar]
- WEBSTER D. A SIMPLE METHOD OF SERUM PROTEIN FRACTIONATION ON CELLULOSE ACETATE AND A COMPARISON OF THE ALBUMIN LEVELS WITH A METHOD OF SODIUM SULPHITE FRACTIONATION. Clin Chim Acta. 1965 Feb;11:101–112. doi: 10.1016/0009-8981(65)90202-0. [DOI] [PubMed] [Google Scholar]
