Table I. Comparison of vCKBPs encoded by different viruses.
| Class | Virus and protein | Chemokine binding specificity | Mechanism of action |
|---|---|---|---|
| vCKBP-1 | MV M-T7 | CC, CXC, C | Secreted, blockade of chemokine–GAG interactions |
| vCKBP-2 | MV M-T1VV 35 kDa | CC | Secreted, blockade of chemokine–receptor interactions |
| CPV CCI | |||
| vCKBP-3 | MHV-68 M3 | CC, CXC, C, CX3C | Secreted, blockade of chemokine–receptor and chemokine–GAG interactions |
| vCKBP-4 | Alphaherpesvirus isoforms of gG | CC, CXC, C | Secreted and membrane bound, blockade of chemokine–receptor and chemokine–GAG interactions |
CCI, chemokine inhibitor; GAG, glycosaminoglycan; gG, glycoprotein G; MHV-69, murine gammaherpesvirus 68; MV, myxoma virus; vCKBP, viral chemokine binding protein; VV, vaccinia virus.