Fig. 6. Global topologies of multimodule fibronectin fragments. Solvent-accessible surfaces have been superimposed over ribbon diagrams for the minimized average structure of ⁶F1¹F2²F2, and the crystal structures of ⁷F3⁸F3⁹F3¹⁰F3 (Leahy et al., 1996) and ¹²F3¹³F3¹⁴F3 (Sharma et al., 1999). The fragment structures are mapped onto the mosaic illustration of fibronectin, which has been folded to account for the hairpin structure of ⁶F1¹F2²F2.