Skip to main content
. 2000 Dec 26;98(1):119–124. doi: 10.1073/pnas.011343298

Figure 4.

Figure 4

TSRI265 blocks angiogenesis on the chick CAM without inhibiting the activation of MMP2. (A) Angiogenesis was induced with basic fibroblast growth factor (bFGF) on the CAMs of 10-day chick embryos, and CAMs were treated with either 3 μM TSRI265 or TSRI359. After 72 h, CAMs were harvested and photographed before quantification of the number of branch points within the treatment field (B) and processing of pooled CAMs for SDS/PAGE and zymography (C). The relative migration of the proenzyme and activated MMP2 species is indicated (Left) in kilodaltons. Purified enzyme is shown (Right) as a control (MMP2).