Fig. 2: The main effects, in terms of odds ratios (ORs, shown in the graph as boxes) and 95% confidence intervals (CI, shown as bars), of independent factors predicting the occurrence of intracranial hemorrhage relative to the reference points of age ≤ 65 years, systolic blood pressure ≤ 119 mm Hg and time from symptom onset to treatment ≤ 2 hours (N = 5717). The relative importance of these 3 measures, as indicated by their χ² values, is 15, 17 and 10, respectively. There was a 4-way age– sex– treatment– trial interaction (p = 0.005). The area under the receiver–operator curve (AUC index) for this logistic regression was 0.728.