Fig. 4.

Kinetics of replication and core release from Huh7–Lunet cells transfected with chimeric HCV genomes. (A) Genomes specified at the bottom were transfected into Huh7–Lunet cells, and replication was determined by quantification of intracellular amounts of core protein by using an ELISA. Values were normalized for transfection efficiency by using core protein amounts determined 4 h after transfection. (B) Efficiency of core protein release from cells transfected with HCV genomes specified at the bottom. Shown are the percent values of released core protein relative to intracellular core amounts (A). Representative results of four independent experiments are shown.