TABLE 2.
Position | 30 | 36 | 38 | 39 | 64 | 68 | 75 | 77 | mAb bindinga | αLI domain tetramerbindinga | Predicted binding energy (relative to WT) |
---|---|---|---|---|---|---|---|---|---|---|---|
% of WT | kcal/mol | ||||||||||
WT | L | P | P | K | M | N | T | K | 100 | 100 | 0 |
1 | K | 75 ± 10 | 75 ± 9 | 31.0 | |||||||
2 | Q | 50 ± 12 | 35 ± 6 | 31.4 | |||||||
3 | R | 50 ± 15 | 50 ± 15 | 31.6 | |||||||
4 | F | 105 ± 8 | 138 ± 12 | 30.5 | |||||||
5 | Y | 90 ± 6 | 135 ± 10 | 30.5 | |||||||
6 | E | 100 ± 5 | 120 ± 8 | 31.5 | |||||||
7 | Y | 86 ± 12 | 30 ± 16 | 31.2 | |||||||
8 | W | 55 ± 9 | 110 ± 15 | 30.6 | |||||||
9 | R | 150 ± 10 | 210 ± 30 | 31.3 | |||||||
10 | F | 95 ± 6 | 120 ± 6 | 30.5 | |||||||
11 | Y | 90 ± 7 | 115 ± 8 | 30.5 | |||||||
12 | I | 92 ± 7 | 187 ± 20 | 30.7 | |||||||
13 | Y | E | W | R | F | I | F | 80 ± 12 | 10 ± 10 | 33.4 |
See Table 1 for details.