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. 1970 Jan;18(1):1–6.

Effect of pinealectomy on immune reactions in the rat

B D Janković, Katarina Isaković, Spomenka Petrović
PMCID: PMC1455525  PMID: 4243787

Abstract

Non-inbred Wistar rats were pinealectomized at birth or in adult life, and tested for classical immune responses. Neonatal pinealectomy did not exert any notable effect on immune capacity of rats. On the other hand, rats pinealectomized at 6 weeks of age showed partial and transient impairment of immune potential. Arthus reactivity to bovine serum albumin was diminished and oedema of the skin less pronounced, and delayed reactions were reduced and of short duration. Slight delay in homograft rejection was noted. The incidence of allergic encephalomyelitis was diminished, and no clinical signs were observed. The cellular make-up of lymphoid tissues of pinealectomized adult rats was normal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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