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Some of the strategies for designing targeted adenoviral (Ad) vectors. A) Binding of adenovirus to cells via the knob domain of the fiber to CAR. B) Adenovirus complexed with an anti-knob antibody fails to bind to CAR. C) Conjugation of a specific ligand to the anti-knob antibody would allow virus binding to the targeted receptor on the cell surface. D) Conjugation of anti-receptor antibody to anti-knob antibody would target the Ad vector to the specific receptor on the cell surface.
