TABLE 2.
PPI levels of F2 intercross mice classified by genotypes at the chromosome 16 proximal and distal PPI QTL peaks
| Genotype
|
PPI (%)
|
|||
|---|---|---|---|---|
| Proximal QTL | Distal QTL | N | Mean | Variance |
| F2 intercross progeny | ||||
| B6 | B6 | 10 | 24.3 | 109.9 |
| B6 | Het | 6 | 29.5 | 21.7 |
| B6 | A/J | 1 | 58.6 | NA |
| Het | B6 | 6 | 43.7 | 56.8 |
| Het | Het | 37 | 43.4 | 165.2 |
| Het | A/J | 2 | 59.9 | 16.6 |
| A/J | B6 | 1 | 37.2 | NA |
| A/J | Het | 6 | 30.1 | 216.9 |
| A/J | A/J | 16 | 52.6 | 281.2 |
| Parental strains | ||||
| B6 | 65 | 34.3 | 105.1 | |
| CSS-16 | 54 | 48.9 | 202.1 | |
Mean percentage PPI at an 80-dB prepulse intensity and variance of F2 intercross mice utilized for linkage analyses. Intercross mice are grouped according to the nine genotype combinations of the markers at the peak of the proximal and distal chromosome 16 QTLs, where A/J indicates homozygosity for A/J (CSS-16) alleles, B6 indicates homozygosity for B6 alleles, and Het indicates heterozygosity. PPI data are omitted for two intercross mice that had missing genotypes for the marker at the distal QTL peak. For comparison, mean percentage PPI is shown for the B6 and CSS-16 parental mice tested during the same PPI test sessions at the intercross mice.