Figure 6.
Comparison in response to changes in MEN activity across 10 different different MenG third chromosome lines. MenEx+ and MenEx− flies were crossed to 10 different MenG (Men+i) lines to produce MenEx−/Men+i and MenEx+/Men+i heterozygotes. Each pair of points shows the change in (A) triglyceride concentration (micrograms per microgram protein), (B) G6PD activity, or (C) IDH activity with change in MEN activity (10,000 × μm NADPH/min/μg protein) in a different third chromosome background (Men+i). Values from MenEx−/Men+i flies are shown in open circles, and those from MenEx+/Men+i flies are in closed circles. Pairs of values for each Men+i are connected by a line. Log values are plotted so that the slope of each line is an estimate of the control (A) or elasticity (B and C) coefficient in each line. Note the large difference in MEN values (x-axis) reflecting line-specific differences in MEN activity. Note also the relative constancy in the sign of slope of the lines (direction of interaction) in B and C, but not in A.