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. 2005 Dec;171(4):2097–2112. doi: 10.1534/genetics.105.044750

TABLE 2.

Estimates of the average coefficient of dominance for segregating mutations and other parameters for a model of many mutations of low average effect

Estimates of average h
% chromosomes
n Mean effect by.x R 1/bx.y hDL QN SL D VA VD VA/D
0 (0, 0) 0.07 0.15 0.28 0.09 88 12 0.169 0.0009 0.0005 0.005
50 (25, 25) Inline graphic 0.11 0.22 0.42 0.14 88 12 0.187 0.0017 0.0006 0.010
100 (50, 50) 0.14 0.26 0.51 0.17 86 14 0.210 0.0025 0.0008 0.012
150 (74, 76) 0.18 0.29 0.56 0.20 85 15 0.233 0.0033 0.0009 0.014
300 (149, 151) 0.27 0.35 0.64 0.26 82 18 0.300 0.0057 0.0013 0.019
10 (5, 5) Inline graphic 0.10 0.18 0.39 0.13 88 12 0.179 0.0021 0.0011 0.012
50 (23, 27) 0.21 0.27 0.58 0.23 85 15 0.226 0.0051 0.0017 0.023
100 (47, 53) 0.29 0.32 0.67 0.30 81 19 0.283 0.0092 0.0025 0.032
150 (70, 80) 0.34 0.35 0.71 0.34 75 25 0.332 0.0129 0.0032 0.039
10 (4, 6) Inline graphic
0.16 0.21 0.51 0.20 87 13 0.190 0.0046 0.0019 0.024
50 (21, 29) 0.32 0.32 0.78 0.38 73 27 0.318 0.0182 0.0061 0.057
100 (42, 58) 0.35 0.37 0.95 0.45 51 49 0.486 0.0384 0.0115 0.079
150 (63, 87) 0.35 0.40 1.21 0.48 34 66 0.647 0.0552 0.0168 0.085

Nonlethal mutational parameters: λ = 0.04, Inline graphic.

Other parameters and definitions are as in Table 1. The number of segregating nonpleiotropic mutations in the chromosome sample was 2396 ± 45. Ranges of SE: by.x, 0.002–0.005; R, 0.001–0.004; 1/bx.y, 0.003–0.028; hDL, 0.003–0.008; QN, 0.59–1.35; SL, 0.76–1.40; D, 0.005–0.010; VA, 0.0000–0.0006; and VD, 0.0000–0.0003.