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. 2005 Dec;171(4):2097–2112. doi: 10.1534/genetics.105.044750

TABLE 3.

Estimates of the average coefficient of dominance for segregating mutations and other population parameters for a model where nonantagonistic mutations show strengthening pleiotropy

Estimates of average h
% chromosomes
n by.x R 1/bx.y hDL QN SL D VA VD VA/D
A.
0 (0, 0) 0.04 0.03 0.17 0.05 92 8 0.069 0.0006 0.0006 0.009
3 (1, 2) 0.23 0.17 0.58 0.21 90 10 0.109 0.0082 0.0033 0.075
5 (1, 4) 0.32 0.23 0.68 0.30 87 13 0.151 0.0139 0.0053 0.092
10 (2, 8) 0.38 0.30 0.80 0.41 77 23 0.249 0.0271 0.0102 0.109
15 (3, 12) 0.37 0.33 0.91 0.46 65 35 0.349 0.0401 0.0147 0.115
B.
0 (0, 0) 0.06 0.13 0.25 0.08 93 7 0.100 0.0016 0.0005 0.016
10 (4, 6) 0.19 0.21 0.51 0.22 92 8 0.130 0.0053 0.0016 0.041
50 (21, 29) 0.36 0.33 0.74 0.42 80 20 0.260 0.0195 0.0058 0.075
100 (42, 58) 0.37 0.38 0.90 0.48 60 40 0.416 0.0364 0.0107 0.087
150 (63, 87) 0.37 0.41 1.08 0.50 40 60 0.585 0.0554 0.0162 0.095

Nonlethal mutational parameters: (A) λ = 0.006, Inline graphic (B) λ = 0.04, Inline graphic. The number of segregating strengthening pleiotropic mutations in the chromosome sample was 70 ± 1 for model A and 2102 ± 22 for model B. The mean selection coefficient of antagonistic pleiotropic mutations is Inline graphic. Other parameters and definitions are as in Table 1. Ranges of SE: by.x, 0.001–0.005; R, 0.001–0.005; 1/bx.y, 0.002–0.011; hDL, 0.001–0.008; QN, 0.26–0.79; SL, 0.31–0.69; D, 0.002–0.006; VA 0.0000–0.0010; and VD, 0.0000–0.0004.