TABLE 4.

Estimates of the average coefficient of dominance for segregating mutations and other parameters for a model of few mutations of large average effect, under different population sizes (A) and an asymmetric model of pleiotropy (B)

		Estimates of average h				% chromosomes
N	n	by.x	R	1/bx.y	hDL	QN	SL	D	VA	VD	VA/D
A.
102	0	0.15	0.15	0.33	0.18	98	2	0.018	0.0003	0.0005	0.017
15	0.39	0.34	0.62	0.44	96	4	0.095	0.0074	0.0023	0.078
103	0	0.07	0.07	0.25	0.10	94	6	0.056	0.0003	0.0007	0.005
15	0.35	0.31	0.65	0.37	91	9	0.150	0.0090	0.0029	0.060
105	0	0.03	0.02	0.16	0.03	77	23	0.206	0.0002	0.0013	0.001
15	0.27	0.22	0.72	0.20	73	27	0.296	0.0089	0.0034	0.030
B.
3	0.08	0.15	0.40	0.10	86	14	0.132	0.0014	0.0010	0.011
104	5	0.11	0.22	0.51	0.13	86	14	0.139	0.0021	0.0012	0.015
10	0.18	0.31	0.62	0.19	85	15	0.157	0.0041	0.0015	0.026
	15	0.24	0.35	0.69	0.24	83	17	0.178	0.0060	0.0018	0.034

Nonlethal mutational parameters: λ = 0.006, . N, population size. n, number of antagonistic pleiotropic mutations segregating per chromosome. The mean selection coefficient of antagonistic pleiotropic mutations is . Ranges of SE: b_y.x, 0.001–0.004; R, 0.000–0.003; 1/b_x.y, 0.002–0.008; h_DL, 0.001–0.008; QN, 0.18–0.81; SL, 0.11–0.39; D, 0.001–0.009; V_A, 0.0000–0.0002; and V_D, 0.0000–0.0001. Other parameters and definitions are as in Table 1.