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. 2005 Dec;171(4):2097–2112. doi: 10.1534/genetics.105.044750

TABLE 6.

Estimates of the per generation rate of mutations and the average selection coefficient of mutations by the method of Deng and Lynch (1996)

n Inline graphic Inline graphic Inline graphic Inline graphic
A.
True value: 0.006 0.200 0.006 0.200
0 0.009 0.409 0.012 0.307
3 0.040 0.277 0.071 0.201
10 0.188 0.150 0.265 0.092
B.
True value: 0.040 0.050 0.040 0.050
0 0.022 0.205 0.038 0.131
10 0.030 0.175 0.093 0.105
100 0.394 0.067 0.537 0.014

Mutational parameters: (A) λ = 0.006, Inline graphic (B) λ = 0.04, Inline graphic. n, number of antagonistic pleiotropic mutations segregating per chromosome. The mean selection coefficient of antagonistic pleiotropic mutations is Inline graphic.