Figure 4.

In silico mapping. The association between the reproductive performance of males from the 17 inbred strains analyzed in Figure 3 and 167 diallelic variants distributed across the candidate interval defined by progeny testing is shown. Variants are shown as triangles and the position along the horizontal axis refers to the distance in megabasepairs from the centromere of chromosome 11. The vertical axes show the statistical significance of the association results while the dashed vertical lines denote the proximal and distal boundaries of the candidate interval. In some cases multiple variants with the same degree of association appear as a single triangle. The top plot shows the strength of the associations between genotype and litter size using the Fdistribution to assess the statistical significance of the nested-mixed models. The bottom plot shows the strength of the association between genotype and litter size using permutation tests to assess the statistical significance of our findings. The empirical significance estimates for the SNPs on the figure with the four most significant findings were determined exactly.