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. 2006 Jan;172(1):579–592. doi: 10.1534/genetics.105.051383

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Copyright © 2006 by the Genetics Society of America

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Figure 8. — Methyation analysis of TIRA vs. TIRB. Shown is a Southern blot depicting individuals carrying MuDR(p1)* and that are mop1/mop1 or mop1/+. Individuals were digested with AfeI (a methyl-sensitive enzyme that cuts once within each TIR) and BamHI (not methyl sensitive and that cuts once within the MuDR element as well as outside each TIR). The Southern blot was probed first with the methyl TIRA probe and then stripped and reprobed with the p1 flanking probe. mop1/mop1;MuDR(p1)* individuals are hypomethylated at TIRA but are not hypomethylated at TIRB. Active MuDR is hypomethylated at both TIRA and TIRB. Silenced MuDR and mop1/+;MuDR(p1)* individuals are hypomethylated at neither TIR.