Figure 2.

Neurodegeneration in K⁺ channel mutant animals. Frontal sections of mutants aged to median life span are shown. (A) At day 37 sei^ts1 mutants exhibit significant pathology presented as sporadic vacuoles throughout the central nervous system. The region designated by the square is enlarged at the right as A′–E′. Micrographs showing intermittent brain pathology in eag (B) and Sh (C) mutants at 33 and 35 days, respectively. (D) No gross pathology was ever observed in eag Sh double mutants, which die within 1 week. (E) Aged CS animals display little or no pathology. Bar, 50 μm.