TABLE 1.
Viability and neuropathology of various ion channel mutants
| 50% ± SD | Pathology | 50% ± SD | Pathology | |
|---|---|---|---|---|
| Genotype | +/+ | +/+ | DTS1/+ | DTS1/+ |
| +/Y | 38 ± 4.4 | 0/1 | 14 ± 0.8 | 4 |
| eag/Y | 33 ± 1.7 | 1 | 14 ± 2.1 | 3/4 |
| Sh/Y | 35 ± 2.6 | 1 | 16 ± 3.4 | 3 |
| eag Sh/Y | 7 ± 2.1 | 0 | 7 ± 0.7 | NA |
| seits1/seits1 | 37 ± 0.5 | 2 | NA | NA |
| napts1/napts1 | 27 ± 1.9 | 1 | NA | NA |
| parats1/Y | 37 ± 1.5 | 1/2 | 6 ± 1.1 | 0/1 |
| +/+ | 38 ± 4.4 | 0/1 | 23 ± 3.4 | 4 |
| eag/+ | 47 ± 0.7 | NA | 21 ± 1.4 | NA |
| Sh/+ | 39 ± 16.2 | NA | 31 ± 6.1 | NA |
| eag Sh/+ | 36 ± 4.2 | NA | 24 ± 3.5 | 3/4 |
| seits1/+ | 39 ± 2.4 | NA | 23 ± 2.1 | 4 |
| parats1/+ | 48 ± 3.3 | 2 | 16 ± 5.3 | 4 |
Viability is assessed as median age (50%). Error is standard deviation (SD). Genotype in column heading represents the third chromosome. DTS1 indicates ATPαDTS1. Neuropathology was scored 0 (none) to 5 (marked).