Figure 7.
HO expression is reduced in mutant strains. (A) RNA was prepared from strains DY150 (wild type) and DY7462 [mot1(R1243I)] grown at either 25° or 30° and used for S1 nuclease protection assays to measure HO, CLN2, and CMD1 (internal control) RNA levels. (B) RNA was prepared from strains DY150 (wild type), DY7463 [mot1(R1243I)], DY5265 (gcn5), DY7841 [gcn5 mot1(R1243I)], DY7139 (nhp6ab), and DY7847 [nhp6ab mot1(R1243I)] grown at 25° and used for S1 nuclease protection assays to measure HO and tRNA–Trp (internal control) RNA levels.