Skip to main content
. 2006 Apr;172(4):2309–2324. doi: 10.1534/genetics.104.035170

TABLE 2.

Mapped and identified modifiers

Gene Cytological site Accession no. Allelea Mutationsb Phenotypes in Psn mutant backgroundcd Gene identification methods (maximal interval defined by SNPs, phenotype mapped)e
dac 36A1 NM_165161 MEE-2* 367–794 DEL and FS Enhanced eye Meiotic (40 kb, enhanced eye) and noncomplementation with dac[3] and dac[4]
MHE-1 Y259N Enhanced eye
SFE-8* C272Y; 887–1074 DEL and FS Enhanced eye
dp 24F4–25A1 NM_175960.2 MFE-1* Not determined Notal pits Meiotic (7 Mb, notal pits) and noncomplementation with CyO dp[lvI], Df(2L)dp-h25, dp[olvR], Tp(2;3)dp[h27], and dp[olvDG10]
PGE-8 Not determined Enhanced eye
PHE-5 Not determined Lethal
PIE-10* Not determined Notal pits
eya 26E1–E2 NM_078768 SJE-1 Translocation Enhanced eye Cytology, in situ
SLE-2 Not determined Enhanced eye
γ-Tub23C 23C3–C4 NM_057456 bmps1d* M382I Enhanced eye, wing bumps and notching Meiotic (26.1 kb, enhanced eye)
bmps2* M382I Enhanced eye, wing bumps and notching
bmps3 P358L Enhanced eye, wing bumps and notching, vein thickening
bmps4 P358L Enhanced eye, wing bumps and notching, vein thickening
bmps5 P358L Enhanced eye, wing bumps and notching, vein thickening
so 43C1 NM_057385 SHE-7* R274Q Enhanced eye Meiotic (48 kb, enhanced eye)
SKE-1d* 281–416 DEL Enhanced eye
Spt5 56D5–D7 NM_144353 MGE-3* K236* Enhanced eye Meiotic (36.2 kb, enhanced eye)
SIE-27* Q632* Enhanced eye
S 21E2–E3 NM_078726 16 alleles Not determined Enhanced eye Noncomplementation with S[BTE]
vg 49E1 NM_078999 PHE-4 Not determined Wing notching Noncomplementation with Df(2R)vg133 and vg[1]
SDE-1 Splice @435 Enhanced eye, wing notching
SGE-4 Q349* Wing notching
SGE-11 Not determined Enhanced eye, wing notching
AP-47 85D24 NM_141649 SAE-10* S366N Enhanced eye, vein thickening Meiotic (85 kb, enhanced eye)
SHE-11* 146–158 DEL and FS Enhanced eye, vein thickening, low penetrance pupal lethal
Dl 92A1–2 NM_057916 MIE-19 W252* Lethal Meiotic (86 kb, enhanced eye) and noncomplementation with known alleles
MIE-22* C433S; C506W Enhanced eye, vein thickening
PFE-5 C488Y Lethal
PFE-6 1–20 DEL Enhanced eye, vein thickening
PGE-2 1st exon deleted Enhanced eye, vein thickening
SDE-4* C538R Enhanced eye, vein thickening
SHE-5 C362Y Wings held out, wing notching
SHE-11 Splice @124 Enhanced eye, vein thickening, low penetrant pupal lethal
SIE-36 Translocation Vein thickening, low penetrant pupal lethal
gl 91A3 NM_057506 SAE-9d R466* Enhanced eye Noncomplementation with gl[2], gl[3]
H 92F3 NM_079694 PFE-1 Not determined Bristle shaft to socket transformations, vein loss Noncomplementation with known alleles
PGE-1 Not determined Bristle shaft to socket transformations, vein loss
PGE-4 Not determined Bristle shaft to socket transformations, vein loss
PGE-6 Not determined Bristle shaft to socket transformations, vein loss
SDS-1 Not determined Suppressed eye, bristle shaft to socket transformations, vein loss
SLS-1 Not determined Suppressed eye, bristle shaft to socket transformations, vein loss
hh 94E1 NM_079735.3 PIE-7* G257D Enhanced eye, extra vein material between veins 2 and 3 Meiotic (161 kb, enhanced eye) and noncomplementation with known alleles
SCE-2 Translocation Enhanced eye, wing notching
SFE-4 284–462 DEL and FS Enhanced eye
SGE-2 N141I Enhanced eye
SHE-2* S286N Enhanced eye
SLE-1* Uncharacterized deletion Enhanced eye
kkv 83A1 NM_079509 A1 G824D Enhanced eye Cytology, in situ on a transposition that fails to complement this groupf
BM1 P764N Enhanced eye
SIE-29 I1043N Enhanced eye
Nsf2 87F15 NM_176499 A6d* A597V Enhanced eye Meiotic (24 kb, enhanced eye)
A15* 555–641 DEL and FS Enhanced eye
nct 96B1 NM_143040 PIE-6 Point mutation in 3′ UTR Enhanced eye Meiotic (1.46 Mb, enhanced eye)
SGE-3 K476* Enhanced eye
SGE-8 Q177* Enhanced eye, wing vein thickening and notching
SGE-9 R273C Enhanced eye, wing vein thickening and notching
SGE-10* Uncharacterized deletion Enhanced eye
SIE-28* Not determined Enhanced eye, wing vein thickening and notching
SIE-22 C272Y Enhanced eye, wing notching, missing microchaetae
Opa 82E1 NM_079504 A3 Uncharacterized deletion Enhanced eye, tufted vibrissae Cytology, in situ
B28 Y275N Enhanced eye, tufted vibrissae
SIE-19 Y242D Enhanced eye, tufted vibrissae
SIE-24 Q104* Enhanced eye, tufted vibrissae
SJE-2 Translocation Enhanced eye, tufted vibrissae, wing notching
SKE-5 Uncharacterized deletion Enhanced eye, tufted vibrissae
Psn 77C3 NM_079460 9 L499Q Enhanced eye Sequencing lethal and viable noncomplementers
DIE-2g Q244* Lethal
MIE-5g Not determined Lethal
MIE-12g Q523* Lethal
MIE-15g Not determined Lethal
PIE-11g G446S Lethal
SIE-5g D110L Lethal
R 62B7 NM_057509 PIE-6d L120F Enhanced eye Noncomplementation with R[1]
Ras85D 85D21 NM_057351 MAE-2* M67I Enhanced eye Meiotic (106 kb, enhanced eye) and noncomplementation with Ras85[D06677] and Ras85[D05703]
MDE-7* G60S Enhanced eye
a

Meiotically mapped alleles are indicated by an *.

b

The mutation for each allele is indicated. Amino acid numbers are derived from the reference sequence listed in the accession number column. “Splice @” is defined as a nucleotide change in the donor/acceptor “GU/AG” sequence at the referenced amino acid position. “DEL” refers to a deletion of the referenced amino acids and “FS” refers to a predicted frameshift.

c

Psn background: screen A, Psn143/+ (alleles: 9, bmps1, bmps2, A1, BM1. A6, A15, A3, B28); screen B, Psn9/Psn143 (all other alleles).

d

Phenotypes in a Psn wild-type background were not assessed, with the following exceptions: NSF2A6 (see results), γ-Tub23C (see results), glSAE-9 (homozygous viable and displays a very small eye), soSKE-1 (homozygous viable and displays a very small eye and loss of ocelli), and RPIE-6 (homozygous viable and displays slightly reduced and severely rough eyes).

e

Method(s) of gene identification are indicated for each group. Final meiotic mapping interval and the phenotype mapped are indicated in parentheses. The alleles meiotically mapped for each group are indicated by an * in the “Allele” column.

f

Three additional alleles of kkv were found by testing kkvA1 and kkvBM1 for noncomplementation with a set of lethal mutations within the 82F region recovered by Carpenter (1999). One of these alleles consisted of an X-ray-induced transposition [T(2;3)82Fh2], which was used to cytologically locate the gene by in situ hybridization analysis on polytene chromosomes.

g

These alleles also carry the Psn9 L499Q mutation in cis to the reported mutation.