TABLE 1.
SNPs in candidate genes examined in four populations
| Heterozygosity
|
|||||
|---|---|---|---|---|---|
| Gene (no. SNPs; kb covered) | Population | Mean | Range | No. haplotypes | Gene diversity (%) |
| BMP4 (8; 8.32) | EA | 0.393 | (0.074, 0.452) | 17 | 76.4 ± 1.70 |
| CS | 0.422 | (0.085, 0.504) | 7 | 68.7 ± 2.97 | |
| MS | 0.434 | (0.131, 0.505) | 12 | 81.3 ± 2.80 | |
| IS | 0.428 | (0.106, 0.503) | 10 | 81.3 ± 2.32 | |
| EGF (6; 29.65) | EA | 0.412 | (0.156, 0.489) | 11 | 55.5 ± 2.62 |
| CS | 0.387 | (0.101, 0.503) | 6 | 74.7 ± 1.86 | |
| MS | 0.400 | (0.126, 0.493) | 8 | 76.7 ± 2.37 | |
| IS | 0.411 | (0.123, 0.505) | 7 | 72.7 ± 2.90 | |
| FGFR2 (8; 49.72) | EA | 0.344 | (0.119, 0.511) | 16 | 81.8 ± 1.33 |
| CS | 0.202 | (0.053, 0.502) | 10 | 74.6 ± 2.76 | |
| MS | 0.199 | (0.045, 0.501) | 9 | 69.6 ± 3.58 | |
| IS | 0.279 | (0.022, 0.493) | 9 | 80.4 ± 1.95 | |
| NEDD9 (5; 68.14) | EA | 0.403 | (0.244, 0.526) | 10 | 84.3 ± 0.87 |
| CS | 0.219 | (0.018, 0.460) | 7 | 65.4 ± 3.80 | |
| MS | 0.253 | (0.022, 0.497) | 7 | 76.6 ± 2.30 | |
| IS | 0.290 | (0.123, 0.486) | 10 | 73.4 ± 4.16 | |
| MMP13 (6; 12.43) | EA | 0.344 | (0.111, 0.437) | 8 | 58.4 ± 2.70 |
| CS | 0.405 | (0.068, 0.497) | 5 | 71.2 ± 2.10 | |
| MS | 0.386 | (0.022, 0.503) | 5 | 66.0 ± 3.05 | |
| IS | 0.417 | (0.161, 0.505) | 6 | 68.7 ± 2.66 | |
| EDN1 (3; 5.15) | EA | 0.420 | (0.368, 0.500) | 5 | 65.4 ± 1.48 |
| CS | 0.428 | (0.400, 0.470) | 4 | 52.5 ± 3.91 | |
| MS | 0.466 | (0.441, 0.493) | 5 | 58.1 ± 3.82 | |
| IS | 0.493 | (0.477, 0.502) | 4 | 56.8 ± 3.01 | |
| GABRB3 (4; 3.03) | EA | 0.434 | (0.371, 0.499) | 6 | 60.6 ± 2.13 |
| CS | 0.369 | (0.247, 0.442) | 5 | 50.7 ± 5.08 | |
| MS | 0.399 | (0.296, 0.470) | 4 | 55.3 ± 5.04 | |
| IS | 0.482 | (0.468, 0.497) | 4 | 65.7 ± 1.92 | |
| GPC1 (4; 1.21) | EA | 0.427 | (0.391, 0.484) | 10 | 77.9 ± 0.93 |
| CS | 0.380 | (0.203, 0.455) | 6 | 51.6 ± 4.69 | |
| MS | 0.365 | (0.167, 0.481) | 5 | 60.3 ± 5.11 | |
| IS | 0.479 | (0.471, 0.490) | 4 | 66.6 ± 1.94 | |
| ZNF509 (3; 2.77) | EA | 0.440 | (0.407, 0.502) | 3 | 61.8 ± 1.60 |
| CS | 0.392 | (0.335, 0.422) | 3 | 63.1 ± 2.29 | |
| MS | 0.363 | (0.324, 0.442) | 3 | 63.5 ± 2.43 | |
| IS | 0.308 | (0.213, 0.497) | 3 | 60.5 ± 2.29 | |
| LYAR (4; 2.08) | EA | 0.418 | (0.404, 0.424) | 5 | 44.1 ± 2.38 |
| CS | 0.476 | (0.429, 0.492) | 4 | 66.8 ± 1.40 | |
| MS | 0.452 | (0.337, 0.490) | 3 | 57.5 ± 4.03 | |
| IS | 0.351 | (0.179, 0.410) | 3 | 43.8 ± 5.44 | |
| RBP1-RBP2 (3; 76.33) | EA | 0.402 | (0.308, 0.490) | 7 | 61.7 ± 2.79 |
| CS | 0.237 | (0.132, 0.404) | 5 | 51.3 ± 4.38 | |
| MS | 0.326 | (0.250, 0.406) | 5 | 54.0 ± 5.17 | |
| IS | 0.382 | (0.245, 0.499) | 6 | 66.6 ± 3.85 | |
EA, European-American (2n = 270); CS, Chinese-Singaporean (2n = 114); MS, Malay-Singaporean (2n = 90); IS, Indian-Singaporean (2n = 92).