Figure 3.

Coronal fused SPECT (color) and CT (gray-scale) image of a dog with (top left) and without (top middle) MI during the first hours after intravenous injection of ¹¹¹In oxine–labeled MSCs showing predominant lung uptake with increased uptake to the dependent left lung (green-yellow color toward right). In a dog with MI that received ¹¹¹In oxine without MSCs (top right), the tracer behaves primarily as a blood pool agent, with uptake visible in left and right ventricles of the heart. A reference marker (arrow) containing ¹¹¹In oxine was placed on the chest wall on the dog that did not receive MSCs (top right). Redistribution of ¹¹¹In oxine–labeled MSCs to predominantly the liver occurs at 24 hours after intravenous injection in both a representative infarcted (bottom left) and noninfarcted (bottom middle) dog. In an infarcted dog injected intravenously with ¹¹¹In oxine only (ie, no MSCs), a similar pattern of redistribution to the liver is observed at 24 hours after injection (bottom right).