TABLE 1.
GMR-dRetMEN2 genetically interacts the Ras, Src, and JNK pathways
| Gene | Gene function | Allele | GMR-dRetWT | GMR-dRetMEN2A | GMR-dRetMEN2B |
|---|---|---|---|---|---|
| spitz | dEGF receptor ligand | spitzs3547 | WS(65) | WS(86) | |
| spitz01068 | WS(46) | ||||
| spitz1 | WS(40) | WS(56) | |||
| drk | Ortholog of Grb2 protein | drkk02401 | N | N | SS(95) |
| drkk13809 | WS(23) | N | WS(100) | ||
| drk10626 | MS(100) | WS(24) | SS(100) | ||
| Sos | RasGTP-exchange factor | Sos34Ea-6 | SS(100) | ||
| Gap1 | RasGTPase activating factor | Gap1B2 | ME(86) | SE(100) | SE(97) |
| Ras85D | Ras ortholog | Ras85D06677 | MS(100) | WS(76) | |
| Ras85DΔc40b | WS(67) | ||||
| ksr | Kinase suppressor of Ras | ksrS-627 | N | MS(100) | |
| ksrj5E2 | WS(18) | WS(84) | WS(67) | ||
| phl | Raf kinase | phl11.29 | N | ||
| phlPB26 | N | ||||
| Dsor | MAP kinase kinase | Dsor1 | N | ||
| Src64B | Src kinase ortholog | Src64BP1 | WS(86) | WS(65) | |
| Src42A | Src kinase ortholog | Src42Ak10108 | WS(50) | WS(74) | |
| bsk | c-jun kinase (JNK) | bsk1 | WS(47) | WS(44) | |
| bsk2 | WS(43) | WS(86) | |||
| Jra | c-jun transcription factor | JraIA109 | WS(46) | WS(56) | WS(61) |
| dock | Ortholog of Nck adaptor | dockk13421 | N | ||
| dock04723 | N | ||||
| dsh | Wnt, JNK signaling | dsh3 | N | N | |
| dsh6 | N | N | N |
Genetic interactions are indicated according to strength of the phenotype: W, weak; M, moderate; and S, strong; and the type of interaction: S, suppressor; E, enhancer; N, no interaction. WE, for example, indicates a weak enhancer. Parentheses indicate penetrance of the interaction as a percentage.