TABLE 2.
Deficiencies suppress GMR-dRetWT, GMR-dRetMEN2A, and GMR-dRetMEN2B
| Deficiency | Breakpoints | GMR-dRetWT | GMR-dRetMEN2A | GMR-dRetMEN2B | Candidate gene, alleles tested | Interaction |
|---|---|---|---|---|---|---|
| Df(2L)net-PMF | 21A1;21B8 | WS(100) | WS(86) | WS(83) | kismet: kisk10237, kisk13416 | WS |
| Df(2L)al | 21B8;21D1 | SS(100) | MS(100) | SS(100) | ebi: ebik16213 | WS |
| Df(2L)TW161 | 38A6;40B1 | WS(75) | SS(96) | SS(100) | diaphanousa: diak07135 | N |
| dRet | — | |||||
| Df(2R)X58-12 | 58D1;59A | MS(80) | SS(100) | SS(100) | plexus: pxk08316 | WS |
| Df(2R)59AD | 59A1;59D4 | WS(78) | SS(100) | SS(100) | — | |
| Df(3L)Pc-2q | 78C5;79A1 | MS(100) | WS(100) | WS(100) | SAKb: SAKc06612 | N |
| Df(3R)ME15 | 81F3;82F7 | MS(90) | SS(97) | SS(100) | Gelsolinc | — |
| Df(3R)Antp17 | 84A5;84D14 | WS(67) | SS(100) | MS(100) | — | |
| Df(3R)Hu | 84A6;84B6, 84D4;84F2 | WS(76) | MS(100) | MS(82) | — | |
| Df(3R)by10 | 85D8;85F1 | nt | WS(97) | WS(77) | Ras85D: Ras85D06677, Ras85DΔc40b | WS-MS |
| Df(3R)DG2 | 89E1;91B2 | SS(100) | SS(100) | SS(100) | glass: gl2 | SS |
| Df(3R)Cha7 | 90F1;91F5 | WS (89) | WS(100) | WS(100) | glass: gl2 | SS |
Each deficiency is listed by name. The cytological breakpoints for each are derived from the FlyBase and Bloomington Stock Center online databases. Genetic interactions are indicate according to strength of phenotype: W, weak; M, moderate; S, strong; and type of interaction: S, suppressor; N, no interaction; nt, not tested. Therefore, SS is a strong suppressor. Parentheses indicate the penetrance of the interaction calculated as a percentage. See text for details on candidate genes. —, indicates that there were no mutants in the candidate gene available for testing.
dia encodes a formin homology protein involved in cytoskeleton remodeling and Rho signaling (Prokopenko et al. 1999).
Encodes a serine/threonine kinase, which is a putative effector of Src signaling (Yamashita et al. 2001).
Gelsolin encodes an actin-binding protein linked to Src signaling (Chellaiah et al. 2000).