TABLE 2.
H modifiers involved in cell death
| Gene | GOF/LOF | GMR-p53 | GMR-hid | GMR-rpr | GMR-grim |
|---|---|---|---|---|---|
| Factors with general influence | |||||
| anterior open | LOF | S | S | S | S |
| Arflike at 72A | LOF | E | E | E | E |
| CG3600 | GOF | S | S | S | S |
| CG30465 (antisense) | GOF | S | S | S | S |
| CG32521 | GOF | S | S | S | S |
| CG32737 | GOF | S | S | S | S |
| DER activated | GOF | S | S | S | S |
| Dorsal switch protein | GOF | S | S | S | S |
| LOF | E | E | E | E | |
| hemipterous | LOF | S | S | S | S |
| IGF-II mRNA bind protein | GOF | S | S | S | S |
| klumpfuss | LOF | S | S | S | S |
| pointed | GOF | S | S | S | S |
| puckered | LOF | E | E | E | E |
| reaper, hid, grim | LOF | S | S | S | S |
| Rho1 | LOF | E | E | E | E |
| thread | GOF | S | S | S | S |
| LOF | E | E | E | E | |
| Factors with influence on hid, rpr, and grim | |||||
| brahma | LOF | — | E | E | E |
| leonardo | LOF | S | — | S | S |
| nejire | LOF | — | S | S | S |
| sine oculis | LOF | — | E | E | E |
| Factors with specific influence on two or one proapoptotic gene | |||||
| p53 and grim | |||||
| CG2446 | GOF | S | — | — | S |
| CG5261 | GOF | S | — | — | S |
| Delta | LOF | E | — | — | E |
| Hairless | LOF | S | — | — | S |
| lilliputian | LOF | S | — | — | S |
| Notch | GOF | S | Lethal | Lethal | S |
| Suppressor of Hairless | GOF | S | — | — | S |
| widerborst | GOF | S | — | — | S |
| p53 and hid | |||||
| bantam | GOF | S | S | — | — |
| CG11779 | GOF | S | S | — | — |
| rhomboid | GOF | S | S | — | — |
| hid and reaper | |||||
| disc overgrown | GOF | — | S | S | — |
| nuclear fallout | GOF | — | S | S | — |
| reaper and grim | |||||
| Casein kinaseI | GOF | — | — | S | S |
| CG7752 | GOF | — | — | S | S |
| CG13791 (antisense) | LOF | — | — | S | S |
| Factors that influence one proapoptotic gene | |||||
| bazooka | LOF | — | — | S | — |
| Cyclin B | LOF | — | E | — | — |
| dishevelled | LOF | — | E | — | — |
| elbowB | GOF | S | — | — | — |
| l(2)k10113 | GOF | — | S | — | |
| tribbles | GOF | — | S | — | — |
| turtle | LOF | S | — | — | — |
| Enhancement and suppression | |||||
| defective proventriculus | LOF | S | E | E | — |
Suppressors identified in the gain-of-function screen (GOF) as well as all GMR>H modifiers from the loss-of-function screen (LOF) were crossed to flies overexpressing p53, hid, rpr, or grim in the GMR pattern. S, suppression; E, enhancement; −, no phenotypic change. Factors were subdivided into the following four categories: factors that generally influenced all proapoptotic genes and those that modified three, two, or just one factor. One factor, dev, enhanced p53 misexpression phenotypes, but rescued those of hid, rpr, and grim.