TABLE 3.
Deficiency screen for modifiers of GMR>H
| Name | Cytology | Modificationa | Candidate genesb | Modificationc | Cell deathd |
|---|---|---|---|---|---|
| Df(1)N-8 | 3C2-3; 3E3-4 | E2 | Notch(N5419) | Lethal | + |
| diminuitive (dm1) | Lethal | − | |||
| Df(1)C52 | 8E; 9C-D | S1 | nejire(nej3) | S1 | + |
| Df(1)v-N48 | 9F; 10C3-5 | E2 | dishevelled(dsh1) | E3 | + |
| Df(1)N105 | 10F7; 11D1 | S1 | smrter (smrG0361) | S1 | − |
| Df(1)N12 | 11D1-2; 11F1-2 | S1 | hemipterous (hepv39, v75) | S1 | + |
| multiple edematous wings (mewM6) | S1 | − | |||
| Df(1)sd72b | 13F1; 14B1 | S1 | scalloped(sdETX4) | S1 | − |
| Df(1)4b18 | 14B8; 14C1 | Lethal | Dorsal switch protein(Dsp1) | Lethal | + |
| Df(1)r-D1 | 14C2-4; 15B2-C1 | S2 | inflated (ifB2) | S1 | − |
| Rho-kinase (rok1) | S1 | − | |||
| Df(1)B25 | 15D3; 16A4-6 | E1 | Bar (B1) | E1 | − |
| bazooka (baz4) | S1 | + | |||
| Df(1)BK10 | 16A2; 16C7-10 | E1 | Bar (B1) | E1 | − |
| Df(1)HF396 | 18E1-2; 20E-F | S1 | amnesiac(amn1) | S1 | − |
| Df(2L)dp-79b | 22A2-3; 22D5-E1 | S1 | anterior open(aop1) | S1 | + |
| Df(2L)C144 | 22F3-4; 23C3-5 | S2 | lilliputian (lilliA17-2, 00632) | S2 | + |
| Df(2L)JS17 | 23C1-2; 23E1-2 | S1 | lilliputian (lilliA17-2, 00632) | S2 | + |
| Df(2L)sc19-8 | 24C2-8; 25C8-9 | S1 | echinoid (edk01102) | S1 | — |
| fat (ftG-rv) | S2 | — | |||
| turtle (tutlk14703) | S1 | + | |||
| Df(2L)sc19-4 | 25A5; 25E5 | E1 | thick veins (tkv1) | S1/2 | nt |
| Df(2R)cn9 | 42E; 44C | E1 | sine oculis (so1) | E1 | + |
| Df(2R)B5 | 46A; 46C | E1 | crossbronx (cbx05704) | S1 | — |
| dacapo (dap4) | S2 | — | |||
| Df(2R)X1 | 46C; 47A1 | S1 | crossbronx (cbx05704) | S1 | — |
| leonardo (leo07103) | S1 | + | |||
| Df(2R)Jp8 | 52F5-9; 52F10-53A1 | E2 | Rho1 (Rho1E.10) | E2 | + |
| Df(2R)X58-12 | 58D1-2; 59A | E2 | Cyclin B (CycB2) | E1 | + |
| defective proventriculus (dve01738) | S1 | + | |||
| Df(3L)HR232 | 63C1; 63D2 | S1 | sprouty (sty226) | S1/2 | — |
| Df(3L)GN24 | 63F6-7; 64C13-15 | S1 | Rpd3(Rpd304556) | S1 | − |
| Df(3L)vin2 | 67F2; 68D6 | S2 | klumpfuss (klu09036) | S1/2 | + |
| Df(3L)brm11 | 71F1-4; 72D1-10 | E2 | brahma (brm2) | E2/3 | + |
| thread(th4) | E2 | + | |||
| Arflike at 72A (Arf72AN6) | E2 | + | |||
| Df(3R)p712 | 84D4-6; 85B6 | E1/2 | puckered (pucE69) | E2 | + |
| Df(3R)e-N19 | 93B; 94A | E1 | Calcium/calmodulin dependent | ||
| protein kinase (CakiX-307) | E1 | − | |||
| Df(3R)TI-P | 97A; 98A1-2 | E1 | Serrate (SerRX102) | E1 | − |
Listed are those modifying deficiencies in which the responsible loci were identified. Underlined are deficiencies that affect genes also found in the gain-of-function screen and showing an opposite interaction with GMR>H. See Table S2 at http://www.genetics.org/supplemental/ for further modifying deficiencies where no candidates could be assigned.
Modifications were phenotypically categorized according to Figure 2: S, suppressors; E, enhancers.
Identified modifiers with full name (alleles used for the crosses are given in parentheses). Those genes also found in the gain-of-function screen are underlined. Candidate genes that did not interact with GMR>H are listed in Table S2.
Phenotypic classification is according to Figure 2: S, suppressors; E, enhancers.
Interaction with apoptosis-inducing factors were observed (+) or were not observed (−) (for details, see text and Table 2).