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. 2006 May;168(5):1553–1569. doi: 10.2353/ajpath.2006.050240

Figure 2.

Figure 2

Longitudinal peripheral blood counts for CD4+ lymphocytes (a), CD8+ lymphocytes (b), and monocytes (c) of eight CD8-depleted rhesus macaques infected with SIV/DeltaB670. Based on histological findings, macaques were retrospectively classified at postmortem for presence of SIV encephalitis. CD4+ and CD8+ lymphocyte profiles of animals that did or did not develop encephalitis were similar; however, peripheral blood CD4+CD29+ T-helper lymphocytes (d) decreased at 2 weeks after infection in macaques that developed encephalitis. Macaques that developed encephalitis had lower average white blood cell counts before infection or CD8 depletion. a: Peripheral blood absolute CD4+ lymphocyte counts decreased throughout the course of infection. Median peripheral blood absolute CD4+ lymphocyte counts for the three macaques with SIVE are shown in black and the five macaques without encephalitis are shown in gray. b: Peripheral blood CD8+ lymphocytes were suppressed for 2 to 4 weeks in macaques administered cM-T807 during primary infection. Median peripheral blood absolute CD8+ lymphocyte counts for the three macaques with SIVE are shown in black and the five macaques without encephalitis are shown in gray. The asterisk at day 14 after infection indicates a statistically significant difference in the peripheral blood absolute CD8+ lymphocyte count between macaques with and without encephalitis. *P < 0.05. All other time points are not statistically different. c: Peripheral blood absolute monocyte counts were not statistically different between macaques with and without encephalitis. Median peripheral blood absolute monocyte counts for the three macaques with SIVE are shown in black and the five macaques without encephalitis are shown in gray. d: Peripheral blood CD4+CD29+ T-helper lymphocytes decreased earlier in macaques that developed SIVE. Median percentage of peripheral blood T-helper lymphocytes (% CD4+CD29+/total % CD4+ cells) for the three macaques with SIVE are shown in black and the five macaques without encephalitis are shown in gray.