Figure 1.

A diagram of the KRAB-ZNF cluster on HSA19p12 containing genes related to the ZNF91 subfamily. The map shows the physical order of the KRAB-zinc finger loci in the cluster, but is not scaled for genomic distances or relative size. Each finger-containing locus is represented by a blue arrow pointing 5′ to 3′ (left-to-right above the line, opposite strand, below). Loci that contain a KRAB have a red bar at the 5′ end of the symbol. Isolated red bars are KRAB-only pseudogene fragments (not labeled). Locus designations with the format “LLNLxxx” are from the new zinc finger catalog (Huntley et al. 2006) and are here used for pseudogene loci (light-gray text). Colored boxes beneath loci correspond to clade membership in the phylogeny (Fig. 3). In some cases, labeled genes in the cluster maps were not included in the phylogeny in Figure 3 because the spacer region used to create the phylogeny was modified or deleted from the locus, or because they were very divergent and not members of the ZNF91 subfamily, notably the “KRAB-C subfamily” loci (blue outline boxes). The relative positions of β-satellite repeat blocks between loci in this cluster are indicated by green ovals between the lines.