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. Author manuscript; available in PMC: 2007 May 1.
Published in final edited form as: Am J Physiol Regul Integr Comp Physiol. 2005 Dec 22;290(5):R1309–R1323. doi: 10.1152/ajpregu.00555.2005

Figure 8.

Figure 8.

Clock gene knockdown disrupts diurnal rhythms of CORT secretion, but not PRL secretion. (A) Serum PRL did not display a significant diurnal rhythm in RS-ODN animals maintained under a 12:12 L:D cycle. Treatment with AS-ODN failed to affect PRL secretion in these animals as we did not observe a significant difference at any time between AS or RS-injected animals. (B) Serum CORT exhibited a significant diurnal rhythm in RS-ODN-treated rats with a rise to peak at CT0 that was abolished by AS-ODN treatment. Data from RS (dashed line)-treated animals are double-plotted, while data from AS animals (solid line) are single plotted on the right. Data are mean values + SEM for n=4 rats. Differing letters within treatment (lowercase, RS-ODN treated; uppercase, AS-ODN treated) indicate significant effects of time (P < 0.05). * indicates significant peaks above basal level regardless of adjacent differences (P < 0.05). # indicates significant effects of ODN-treatment (P < 0.05).