Table 2.

Effect of antibody against integrin on platelet accumulation on fibrin or fibronectin-fibrin in the absence of soluble fibronectin at a wall shear rate of 1250s^–1

	Adherent platelets, × 10-6 (% inhibition)
Antibody	Fibrin	FN-fibrin
Control	1.8 ± 0.7	5.9 ± 1.2
With mouse IgG1	1.7 ± 0.6 (5)	5.6 ± 1.0 (6)
With rat IgG2	1.6 ± 0.7 (9)	5.3 ± 0.9 (11)
With anti-β3 (7E3)	0.2 ± 0.1 (90)*	0.7 ± 0.3 (88)*
With anti-αIIbβ3 (10E5)	0.2 ± 0.1 (90)*	0.8 ± 0.3 (87)*
With anti-αvβ3 (LM609)	1.0 ± 0.5 (47)*	3.0 ± 1.4 (50)*
With anti-β1 (mAb13)	1.6 ± 0.9 (12)	4.6 ± 1.8 (24)

The luminescence signal was obtained as described in “Materials and methods.” Values represent the mean ± SD of 3 to 4 separate experiments.

^*P < .01 as compared with a control group.