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. 2000 Dec 26;98(1):224–228. doi: 10.1073/pnas.011528898

Figure 4.

Figure 4

Impaired lipolysis in RXRαadL−/− mice during fasting. (A) Fasted RXRαadL−/− mice suffer from hypothermia. Rectal temperature was determined on 10-week-old CT and RXRαadL−/− (KO) mice at the beginning of the light cycle (fed state) and after a 1- or 2-day fast that was started at the beginning of the light cycle. (Error bars, SEM.) *, P < 0.05; **, P < 0.001. (B) Gross appearance of epididymal fat pad after fasting. Testes and epididymal fat pads from 3-month-old CT and RXRαadL−/− (KO) mice after a 2-day fast are presented. (C) Histological analysis of epididymal fat pad. Sections of the epididymal fat pads shown in B were stained with Oil red O. (Scale bar, 20 μm.) (D) Weight of epididymal fat pad. Epididymal fat pad weight of fed and fasted (2 days) 10-week-old CT and KO mice was measured. Values are expressed as the mean ± SEM (n = 9–10). **, P < 0.001; ***, P < 0.0001. (E) Plasma FFA concentrations. FFA was determined in 10-week-old fed and fasted (1 and 2 days) CT and KO mice. Values are expressed as the mean ± SEM (n = 9–10). # indicates values below background levels (dashed line, 0.1 mmol/liter).