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. 1978 Jul;35(1):63–68.

On the mechanism of action of adjuvants.

P Frost, E M Lance
PMCID: PMC1457222  PMID: 79548

Abstract

Evidence is presented that one a way which adjuvants exert their effect is by initiating an enduring increase in the localization of labelled cells in draining lymphoid tissues. Agents not generally considered to be adjuvants (carbon, latex, sheep erythrocytes) but capable of altering lymphocyte recirculation are shown to prevent the induction of tolerance by soluble bovine gamma globulin (BGG). These properties fulfil the criteria for adjuvanticity as defined by Dresser (1968) and link the expression of adjuvanticity to alterations in lymphocyte circulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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