Table 1.
Patient | Clinical Status | Antiretroviral therapy at the time of study* | CD4 count, per μl | CD8 count, per μl | Viral load, copies per ml plasma† | Phenotypes of cultured Virus‡ | HIV Gag specific CD8+ T cells (%)§ |
---|---|---|---|---|---|---|---|
1 | Chronic | Naive | 231 | 802 | 102,927 | X4 | 1.60 |
2 | Chronic | Naive | 62 | 813 | 153,280 | X4 | 0.33 |
3 | Chronic | Naive | 349 | 647 | 102,645 | R5 | 1.21 |
4 | Chronic | Naive | 443 | 996 | 11,990 | R5 | 3.87 |
5 | Chronic | Naive | 85 | 438 | 21,767 | R5 | 0.65 |
6 | Chronic | Naive | 303 | 792 | 54,801 | R5 | 0.33 |
7 | LTNP | Naive | 1,840 | 1,600 | 98 | R5 | ND |
8 | LTNP | Naive | 541 | 727 | 7,257 | R5 | 5.06 |
9 | LTNP | Naive | 563 | 746 | 2,169 | R5/X4 | 0.28 |
10 | Chronic | HAART | 344 | 635 | <50 | R5/X4 | 0.46 |
11 | Chronic | HAART | 320 | 506 | <50 | R5 | 0.09 |
12 | Chronic | HAART + IL-2 | 1,265 | 949 | <50 | R5 | 0.46 |
13 | Chronic | HAART | 327 | 886 | <50 | R5 | 0.08 |
14 | Acute | HAART | 635 | 589 | <50 | R5 | 0.47 |
15 | Acute | HAART | 712 | 751 | <50 | R5 | 0.40 |
16 | Acute | HAART | 778 | 451 | <50 | R5 | 0.13 |
17 | Acute | HAART + IL-2 | 3,064 | 1,328 | <50 | R5 | 0.00 |
HAART contained at least one protease inhibitor and/or one non-nucleoside reverse transcriptase inhibitor and two reverse transcriptase inhibitors of HIV-1.
Measured by ultrasensitive bDNA assay with a detection limit of 50 copies per ml plasma.
Coreceptor usage of isolated virus was evaluated on U87.CD4 cells expressing the chemokine receptors CCR5 or CXCR4.
Determined by measuring INF-γ-positive cells on stimulation with overlapping 20-mer Gag peptides.