Table 1.
Effects of URO-D and HFE genotypes on hepatic iron and porphyrin concentration and URO-D
| Genotype
|
N | Iron, mg/g | Porphyrins, nmol/g | URO-D, nmol/h/mg | |
|---|---|---|---|---|---|
| URO-D | HFE | ||||
| +/+ | +/+ | 4 | 0.13 ± 0.04 | 0.75 ± 0.41 | 1.68 ± 0.09 |
| +/+ | +/− | 5 | 0.15 ± 0.04 | 1.26 ± 0.56 | 1.53 ± 0.14 |
| +/+ | −/− | 3 | 0.73 ± 0.14* | 1.77 ± 1.42 | 1.36 ± 0.06 |
| +/− | +/+ | 8 | 0.11 ± 0.02 | 8.46 ± 4.81 | 0.79 ± 0.07† |
| +/− | +/− | 4 | 0.22 ± 0.05 | 2.13 ± 0.58 | 0.64 ± 0.07† |
| +/− | −/− | 5 | 0.89 ± 0.22* | 259.32 ± 43.15*† | 0.22 ± 0.07*† |
*
Significantly different (P < 0.05) from HFE+/+ and identical URO-D genotype.
†
Significantly different (P < 0.05) from URO-D+/+ and identical HFE genotype.