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. 1980 Jul;40(3):343–352.

Serum protein concentrations during Schistosoma mansoni infection in intact and T-cell deprived mice. II. Immunoglobulin G and antibodies specific for heterologous erythrocytes.

R Musallam, J Bain, A McGregor, M Doenhoff
PMCID: PMC1458060  PMID: 6776032

Abstract

Mice infected with from twenty to fifty Schistosoma mansoni cercariae were found to have elevated serum IgG concentrations following patency of the infection, and the parasite-induced increase in concentration of IgG was dependent on the possession by the host of an intact T-cell lymphocyte pool. Following passive transfer of hyperimmune anti-sheep erythrocyte (SRBC) antibody, there was a more rapid decrease of haemolytic and haemagglutinating antibody titres in S. mansoni-infected, immunologically intact recipients than in uninfected intact mice, and infected or uninfected T-cell deprived mice. However, primary and secondary active immunization with SRBC resulted in similar patterns of serum antibody titre increase and decay in infected and uninfected intact mice over a time course of 140 days. The number of direct and indirect haemolytic plaque-forming (PFC) cells per million spleen cells was similar in S. mansoni-infected and uninfected immunologically intact mice 6 days after either primary or secondary challenge with SRBC. It is concluded that S. mansoni-infected immunologically intact mice challenged with heterologous erythrocytes synthesize anti-erythrocyte antibody at a greater rate than similarly challenged, uninfected mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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