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IL-10 levels after i.v. delivery of Ad/hIL-10 and Ad/vIL-10. After i.v. instillation of 1010 particles of Ad/hIL-10 or Ad/vIL1–0, lung and liver vIL-10 levels were increased significantly as compared with hIL-10 levels, P < 0.001 (A and B). Conversely, serum hIL-10 levels were increased significantly over serum vIL-10 levels after i.v. delivery of the Ad/IL-10 constructs, P < 0.001 (C).
