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. 1980 Oct;41(2):347–352.

Mitogenicity of Entamoeba histolytica extracts for murine lymphocytes.

T Diamantstein, D Trissl, M Klos, D Gold, H Hahn
PMCID: PMC1458163  PMID: 6254869

Abstract

Aqueous extracts or aqueous extracts of delipidated Entamoeba histolytica (E.h.e.) contain a mitogenic principle for murine lymphocytes. As detected by [3H]-thymidine incorporation and blast transformation, E.h.e. acted predominantly on T cells of splenic origin, but not on thymocytes or bone marrow cells. Furthermore, E.h.e. induced proliferation of a subset of non-T-cells which is present in the spleen of athymic nude mice, adhered to nylon wool, but could not be activated to produce antibody. It seems possible that polyclonal activation of lymphocytes by E. histolytica might play a role in the disturbance of the immune system as manifested in the impaired cell mediated immune response of E. histolytica infected hosts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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