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Values for minimal inhibitory concentration of ampicillin and wild-type and mutant β-lactamase-specific activities in a wild-type E. coli strain (XL1-Blue)
| Sample | MIC* | Specific activity† | Relative activity, % |
|---|---|---|---|
| Wild-type | 3,000 | 38 ± 8 | 100 |
| L76N | 100 | 0.4 ± 0.2 | 1.0 |
| M182T | 2,000 | 31 ± 13 | 81.6 |
| L76N/M182T | 2,000 | 15 ± 4 | 39.5 |
MIC (minimal inhibitory concentration) measured in μg/ml of ampicillin. Data from ref. 21.
Specific activity in mM ampicillin per mg of total protein per min at 25 °C.
