Table 1.
Comparative mutagenesis of Fapy·dG and 8-oxo-dG in simian kidney cells
| Experiment | Insert | No. of colonies screened | G→T mutation (%) | G→C mutation (%) |
|---|---|---|---|---|
| 1 | TGA | 117 | 0 (0) | 0 (0) |
| 1 | T(Fapy·G)A | 284 | 23 (8.1) | 0 (0) |
| 2 | T(Fapy·G)A | 201 | 17 (8.5) | 0 (0) |
| Total | T(Fapy·G)A | 485 | 40 (8.2) | 0 (0) |
| 1 | T (8-oxo-G)A | 152 | 10 (6.6) | 0 (0) |
| 2 | T (8-oxo-G)A | 159 | 9 (5.7) | 0 (0) |
| Total | T (8-oxo-G)A | 311 | 19 (6.1) | 0 (0) |
| 1 | TGT | 97 | 0 (0) | 0 (0) |
| 2 | TGT | 142 | 0 (0) | 0 (0) |
| Total | TGT | 239 | 0 (0) | 0 (0) |
| 1 | T(Fapy·G)T | 177 | 45 (25.4) | 4 (2.3) |
| 2 | T(Fapy·G)T | 181 | 61 (33.7) | 0 (0) |
| Total | T(Fapy·G)T | 358 | 106 (29.6) | 4 (1.1) |
| 1 | T (8-oxo-G)Ta | 326 | 78 (23.9) | 0 (0) |
| 2 | T (8-oxo-G)Ta | 271 | 62 (22.9) | 1 (0.4) |
| Total | T (8-oxo-G)Ta | 597 | 140 (23.5) | 1 (0.2) |
aData taken from Ref. (42).