Table 2.
Comparative mutagenesis of Fapy·dA and 8-oxo-dA in simian kidney cells
| Experiment | Insert | No. of colonies screened | A→A* [No mutation] (%) | A*→C mutation (%) |
|---|---|---|---|---|
| 1 | TAA | 208 | 208 (100) | 0 (0) |
| 2 | TAA | 78 | 78 (100) | 0 (0) |
| Total | TAA | 286 | 286 (100) | 0 (0) |
| 1 | T(Fapy·A)A | 161 | 161 (100) | 0 (0) |
| 2 | T(Fapy·A)A | 120 | 119 (99.2) | 1 (0.8) |
| Total | T(Fapy·A)A | 281 | 280 (99.6) | 1 (0.4) |
| 1 | T(8-oxo-A)A | 143 | 141 (98.6) | 2 (1.4) |
| 2 | T(8-oxo-A)A | 120 | 120 (100) | 0 (0) |
| Total | T(8-oxo-A)A | 263 | 261 (99.2) | 2 (0.8) |
| 1 | TAT | 97 | 97 | 0 (0) |
| 2 | TAT | 99 | 99 | 0 (0) |
| Total | TAT | 196 | 196 | 0 (0) |
| 1 | T(Fapy·A)T | 118 | 118 | 0 (0) |
| 2 | T(Fapy·A)T | 100 | 100 | 0 (0) |
| Total | T(Fapy·A)T | 218 | 218 | 0 (0) |
| 1 | T(8-oxo-A)T | 95 | 95 | 0 (0) |
| 2 | T(8-oxo-A)T | 127 | 127 | 0 (0) |
| Total | T(8-oxo-A)T | 222 | 222 | 0 (0) |