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. 1980 Dec;41(4):899–902.

Comparative aspects of the transport of immunoglobulin A from blood to bile.

J G Hall, L A Gyure, A W Payne
PMCID: PMC1458304  PMID: 7461715

Abstract

Polymeric and monomeric human IgA were isolated from the sera of patients with IgA myeloma; rat IgA polymer, monomer and IgG2 were isolated from the ascitic fluid or sera of Lou/Wsl rats bearing appropriate myelomata. The purified Ig preparations were labelled with 125I and injected intravenously into rats, rabbits, guinea-pigs or sheep that had had a cannula inserted into the common bile duct so that their bile could be collected quantitatively. Rats and rabbits transported 30% of the injected dose of both IgA polymers, but no other type of immunoglobulin, from blood to bile within 5--7 h. Sheep and guinea-pigs were unable to transport any of the immunoglobulin preparations from blood to bile, even though the injected material remained circulating in the blood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Birbeck M. S., Cartwright P., Hall J. G., Orlans E., Peppard J. The transport by hepatocytes of immunoglobulin A from blood to bile visualized by autoradiography and electron microscopy. Immunology. 1979 Jun;37(2):477–484. [PMC free article] [PubMed] [Google Scholar]
  2. Brandtzaeg P. Characteristics of SC-Ig complexes formed in vitro. Adv Exp Med Biol. 1974;45(0):87–97. doi: 10.1007/978-1-4613-4550-3_10. [DOI] [PubMed] [Google Scholar]
  3. Brown W. R. Relationships between immunoglobulins and the intestinal epithelium. Gastroenterology. 1978 Jul;75(1):129–138. [PubMed] [Google Scholar]
  4. Hall J. G., Hopkins J., Orlans E. Studies on the lymphocytes of sheep. III. Destination of lymph-borne immunoblasts in relation to their tissue of origin. Eur J Immunol. 1977 Jan;7(1):30–37. doi: 10.1002/eji.1830070108. [DOI] [PubMed] [Google Scholar]
  5. Hall J., Orlans E., Reynolds J., Dean C., Peppard J., Gyure L., Hobbs S. Occurrence of specific antibodies of the IgA class in the bile of rats. Int Arch Allergy Appl Immunol. 1979;59(1):75–84. doi: 10.1159/000232242. [DOI] [PubMed] [Google Scholar]
  6. Jackson G. D., Lemaître-Coelho I., Vaerman J. P., Bazin H., Beckers A. Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile. Eur J Immunol. 1978 Feb;8(2):123–126. doi: 10.1002/eji.1830080210. [DOI] [PubMed] [Google Scholar]
  7. Mach J. P. In vitro combination of human and bovine free secretory component with IgA of various species. Nature. 1970 Dec 26;228(5278):1278–1282. doi: 10.1038/2281278a0. [DOI] [PubMed] [Google Scholar]
  8. Mullock B. M., Hinton R. H., Dobrota M., Peppard J., Orlans E. Endocytic vesicles in liver carry polymeric IgA from serum to bile. Biochim Biophys Acta. 1979 Oct 18;587(3):381–391. doi: 10.1016/0304-4165(79)90442-2. [DOI] [PubMed] [Google Scholar]
  9. Nagura H., Nakane P. K., Brown W. R. Translocation of dimeric IgA through neoplastic colon cells in vitro. J Immunol. 1979 Nov;123(5):2359–2368. [PubMed] [Google Scholar]
  10. Orlans E., Peppard J., Fry J. F., Hinton R. H., Mullock B. M. Secretory component as the receptor for polymeric IgA on rat hepatocytes. J Exp Med. 1979 Dec 1;150(6):1577–1581. doi: 10.1084/jem.150.6.1577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Orlans E., Peppard J., Reynolds J., Hall J. Rapid active transport of immunoglobulin A from blood to bile. J Exp Med. 1978 Feb 1;147(2):588–592. doi: 10.1084/jem.147.2.588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Peppard J. V. Quantitative estimation of IgA in rats: a comparison of two methods. J Immunol Methods. 1979;31(1-2):129–139. doi: 10.1016/0022-1759(79)90293-x. [DOI] [PubMed] [Google Scholar]
  13. Socken D. J., Jeejeebhoy K. N., Bazin H., Underdown B. J. Identification of secretory component as an IgA receptor on rat hepatocytes. J Exp Med. 1979 Dec 1;150(6):1538–1548. doi: 10.1084/jem.150.6.1538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Socken D. J., Underdown B. J. Comparison of human, bovine and rabbit secretory component-immunoglobulin interactions. Immunochemistry. 1978 Jul;15(7):499–506. doi: 10.1016/0161-5890(78)90080-9. [DOI] [PubMed] [Google Scholar]

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