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Acutely blocking the fDR current causes significant reduction in firing rate of SCN neurons during the day. (a) Effect of blocking fDR channels with 0.5 mM 4-AP during the day, early night, and late night in the dSCN. Similar results were obtained with application of 1 mM TEA (data not shown). (b) Blocking fDR channels during the day results in a significantly greater decrease in SFR compared to early and late night.
