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Schematic depiction of the interactions between EGF and EGFR together with their dissociation constants. In Scheme 1, an EGFR in the conformationally extended state (Re) binds EGF (L) with higher affinity than a receptor in the autoinhibited state (R). In Scheme 2, receptors in the extended state can dimerize in both the absence and presence of ligand.
